Searching records...
Showing 20 of 20 results
90b8875661%Six Human PDA Cell Lines (KP4, Miapaca2, Panc1, Patu8902, PK45H, SW1990) were cultured in both normal and serum-free media conditions and then were subjected to Single-Cell RNA Sequqncing.
8be745e160%We performed Single-Cell RNA Sequencing of 7 PDA Cell Lines to characterize and quantify PDA subtypes populations
c55d92ef59%The formation and homeostatic maintenance of cranial sutures rely on cellular activities within the suture mesenchyme. Mesenchymal stem cells in this niche are characterized by self-renewal capacity a…
b8cfd03857%We have employed a single cell sequencing approach using 10x Genomics scRNA-seq to elucidate the transcriptional landscape of the Drosophila larval corpus allatum (CA). As a a sub-organ within the rin…
524b818456%Several Human PDA Cell Lines (ASPC1, PANC1, KP4, HPAFII, PATU8988S, PK45H, S2013, CAPAN1, BXPC3, HPAC, SW1990, MIAPACA2) were cultured and treated with DMSO, Trametinib (TRAM), Hydroxychloroquine (HCQ…
ed845aa755%Transplant rejection is mediated by immune cells, especially T cells. In this study, we employed single-cell RNA sequencing (scRNA-seq) to analyze the states of these cells in response to kidney trans…
8ca66a8154%We have identified a Golgi- and microtubule-rich vesicular structure, termed “Visham”, which resembles the Drosophila fusome and accumulates asymmetrically during germ cell cyst divisions starting at…
c861a29e53%T cells are central mediators of transplant rejection, yet the differentiation trajectories that sustain this process remain incompletely defined. To delineate the differentiation trajectory of CD8+ T…
de0c44a852%Mice bearing intracranial GL261‑CAR tumors were treated intratumorally with PBS (control), oAd, or oAd‑mCD47/PD‑L1‑mIL‑12 (1 × 109 pfu). Tumors were harvested three days after the second viral injecti…
14d3f0be50%Enrichment libraries and Hi-C libraries were processed using identical scripts. Initially, different read types were demultiplexed based on identification sequences in the R2 read. For RNA data, we fi…
569cc67250%Mosquitoes serve as medically significant vectors for transmitting various arboviruses. The mosquito midgut is both the digestive organ and primary infection site via viral bloodmeals, and the midgut…
fd84215650%To analyze the tumor microenvironment characteristics of gastric cancer and its peritoneal metastases, we collected fresh surgical specimens pathologically confirmed as gastric cancer and peritoneal m…
88bd83bd49%To characterize systemic transcriptional changes induced by DHEA treatment, we performed bulk RNA-seq across a panel of tissues collected from control and DHEA-treated mice. Total RNA was extracted fr…
cac0380c49%Assessing anti-tumor immune responses and immune microenvironment alterations in central nervous system (CNS) neoplasms like brain tumors and leptomeningeal disease (LMD) provides prognostic insights…
357c84d548%This study generated RNA sequencing (RNA-seq) data to characterize the transcriptomic consequences of PARylator knockdown in human esophageal squamous carcinoma TE13 cells. Control and PARylator-deple…
0841dc6547%Ovarian cancer is one of the leading causes of cancer-related mortality among women and remains exceptionally difficult to manage and treat effectively in the clinic. Fragile X-related protein 1 (FXR1…
dfd6683746%Despite hundreds of genetic risk loci identified for neuropsychiatric disorders (NPD), most causal variants/genes remain unknown. A major hurdle is that disease risk variants may act in specific biolo…
d89b281046%The amygdala is crucial for emotional memory, but the molecular programs that enable its distinct circuits to encode different memory features remain unclear. Combining single-cell RNA sequencing with…
dc5f68ab46%The aim of this study is to investigate the effect of the combinatorial overexpression of the top GLS MRs in a MOS cell line (at single-cell level).
9299263f46%N6-methyladenosine (m6A) on RNA plays diverse regulatory roles, yet its spatial distribution within tissues remains largely unexplored. Here, we develop a spatial m6A profiling assay leveraging revers…