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8de6315953%We developed long-term resistant (lt-res, several months) pre-clinical models to adavosertib (ADA) and paclitaxel (PTX). We identified distinct transcriptomic and morphological changes in the ovarian…
37e25ca851%This SuperSeries is composed of the SubSeries listed below.
bff5dc4150%Patients with non-small cell lung cancer (NSCLC) who initially respond to Sotorasib, a drug targeting the KRAS G12C mutation, eventually develop acquired resistance. However, the mechanisms driving th…
ceeadb0050%Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options, characterized by high relapse rates and poor survival outcomes due to chemoresistance. This st…
e33d20a845%Acquired resistance to the BRAF inhibitor vemurafenib remains a major obstacle in melanoma therapy. Drug repurposing offers a promising strategy to overcome such resistance. Here, we investigated the…
c981c14e43%Prostate cancer (PCa) is one of the most prevalent malignancies in men and remains a major cause of cancer-related mortality worldwide. While taxane-based chemotherapies, such as docetaxel, are standa…
9bff135741%In this study we used two murine orthtotopic, transplantable synegeneic models, one that displays excellent response (60577) to carboplatin/paclitaxel and one that is highly chemoresistant (HGS2) and…
a050f62e41%Rhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma of skeletal muscle. Worse outcomes are associated with specific subtypes of RMS, including the 10% of fusion-negative tumors that har…
0335825f41%Rhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma of skeletal muscle. Worse outcomes are associated with specific subtypes of RMS, including the 10% of fusion-negative tumors that har…
391fa62741%Rhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma of skeletal muscle. Worse outcomes are associated with specific subtypes of RMS, including the 10% of fusion-negative tumors that har…
3b66018640%Rhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma of skeletal muscle. Worse outcomes are associated with specific subtypes of RMS, including the 10% of fusion-negative tumors that har…
d162917840%Rhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma of skeletal muscle. Worse outcomes are associated with specific subtypes of RMS, including the 10% of fusion-negative tumors that har…
49b446b540%Rhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma of skeletal muscle. Worse outcomes are associated with specific subtypes of RMS, including the 10% of fusion-negative tumors that har…
cf573c3639%The acquisition of immature cell states associated with an emergence of alternative cell fates may result in treatment resistance, yet the transcriptional and epigenetic processes dictating cellular p…
2063e3e239%Cellular senescence is a common outcome of many standard-of-care cytostatic and cytotoxic cancer therapies. Whereas is some contexts therapy-induced senescence can drive tumor growth suppression and a…
004655aa38%Gastroesophageal adenocarcinoma (GEAC) accounts for a significant global cancer burden. Our previous studies demonstrated that YAP1/TEAD are highly expressed in GEAC, and play a critical role in tumor…
3ec881ab38%Pancreatic cancer is a deadly disease as the long-term overall survival rate is only 12%, indicating that there is no effective therapeutic approach available to the patients. Recent studies link the…
7d4b80d138%Triple-negative breast cancer (TNBC) is aggressive, resistant to chemotherapy, and prone to recurrence. While PARP inhibitors (PARPi) help some patients, most do not respond. We developed a novel ther…
03aae05a37%We hypothesized that CAF-induced malignant phenotypes of pancreatic cancer cells may reveal novel therapeutic targets. To explore this possibility, we first analyzed the phenotypic changes in pancreat…
04c73d7136%To study the effects of reduced CS expression on human cancer cell lines, we used small interfering RNAs to knockdown CS, then analyzed the RNA expression profiles of these cells.